HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-amino-N-cyclopropyl-3-iodo-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-3-iodobenzoic acid | HCID 282070 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-amino-N-cyclopropyl-3-iodo-benzamide | HCID 90416663 | — |
Reaction Steps
To 2-amino-3-iodo-benzoic acid (200 mg, 0.76 mmol) in DMF (1 mL) TBTU (244.15 mg, 0.76 mmol) and DIPEA (245.69 μL, 1.52 mmol) are added and stirred at r.t. for 7 min. Cyclopropylamine (52.69 μL, 0.76 mmol) is added and stirred at r.t. overnight. The reaction mixture is diluted with water and the precipitate is filtered off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987249B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-6fab1af941164b65aa058acef57b61b5 |
| Source note | uspto-grants-2015_03 |