Triacetoxyperiodinane → HCID 63557976, compound

HRID 876217Notes

Reaction equation

HRID 876217 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([N:6]2[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]2)[CH2:2]1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C1=CC=CC=2)=O>ClCCl>[O:1]1[CH2:5][CH2:4][CH:3]([N:6]2[CH2:11][CH2:10][C:9](=[O:12])[CH2:8][CH2:7]2)[CH2:2]1

Participants

4

Reactant 2

HCID 159087TriacetoxyperiodinaneHCID 63565343HCID 63565343, compound

Product 1

HCID 63557976HCID 63557976, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To R91.1 1-tetrahydrofuran-3-ylpiperidin-4-ol (200 mg, 1.17 mmol) in dichlormethane (5 mL) is added dess-martin periodine (595 mg, 1.40 mmol) and stirred at r.t. for 5 h. The reaction mixture is filtered through ALOX/N and washed with cyclohexane/ethyl acetate 1:3. The filtrate is concentrated.

Workup

  1. filtrationThe reaction mixture is filtered through ALOX/N
  2. washwashed with cyclohexane/ethyl acetate 1:3
  3. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-c78da69a5d6946ad882cb401242458fa
Source dataset
uspto-grants-2015_03
Patent number
US08987249B2

Reaction notes

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