反应详情

A solution of 1.0 g (3.7 mmol) of methyl [5-(4-ethylphenyl)pyridin-3-yl]carbamate in 100 ml of ethanol and 100 ml of acetic acid was reacted according to General Method 5A. The solution was concentrated under reduced pressure. The crude product was purified by flash chromatography (silica gel, dichloromethane/methanol 4:1). Yield: 171 mg (16% of theory)

1. concentrationThe solution was concentrated under reduced pressure
2. customThe crude product was purified by flash chromatography (silica gel, dichloromethane/methanol 4:1)