4-Morpholinecarbonyl chloride → HCID 66701280, compound

HRID 876232Notes

Reaction equation

HRID 876232 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH:13]([O:15][CH3:16])[CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[N:17]1([C:23](Cl)=[O:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][CH:13]([O:15][CH3:16])[CH2:12][N:11]([C:23]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:24])[CH2:10]2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 66701320HCID 66701320, compound

Product 1

HCID 66701280HCID 66701280, compound

Procedure

880 mg (4.0 mmol) of 3-(4-ethylphenyl)-5-methoxypiperidine and 780 mg (5.2 mmol, 1.3 eq.) of morpholine-4-carbonyl chloride were reacted according to General Method 3A. Yield: 896 mg (58% of theory)

Sources & evidence

ORD record
ord-c9e59d2256a34428a1bbac0ce9c2726c
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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