N-[5-(3,4-dimethylphenyl)pyridin-3-yl]benzamide → N-[5-(3,4-dimethylphenyl)piperidin-3-yl]benzamide

HRID 876237Notes

Reaction equation

HRID 876237 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 1

HCID 66701346N-[5-(3,4-dimethylphenyl)pyridin-3-yl]benzamide

Product 1

HCID 66701309N-[5-(3,4-dimethylphenyl)piperidin-3-yl]benzamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.0 g (3.7 mmol) of N-[5-(3,4-dimethylphenyl)pyridin-3-yl]benzamide in 120 ml of acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. Yield: 1.85 g

Workup

  1. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-94da143fdd7749d8ab388169c853878f
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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