化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 5-bromopyridine-3-carboxylate → Methyl 5-(4-(trifluoromethyl)phenyl)nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| 反応物 | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| 生成物 | Methyl 5-(4-(trifluoromethyl)phenyl)nicotinate | HCID 20099855 | — |
反応手順
28 g (132 mmol) of methyl 5-bromonicotinate and 30 g (158 mmol, 1.2 eq.) of 4-trifluoromethylphenylboronic acid were reacted according to General Method 1A. Yield: 32 g (85% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987248B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-abd5bf5c64f345608450d69abfbfba09 |
| 出典メモ | uspto-grants-2015_03 |