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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876252Generated: October 30, 2026

Potassium tert-butoxide → 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

https://huagongshe.com/reaction/876252

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium tert-butoxideHCID 23665647—
ReactantMethyl 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylateHCID 58002139—
Product1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acidHCID 58002447—

Reaction Steps

22.19 g (39.90 mmol) of the compound from Example 54A and 44.78 g (399.0 mmol) of potassium tert-butoxide were reacted according to the General Method 7A. Yield: 18.29 g (100% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987248B2
Source datasetuspto-grants-2015_03
ORD IDord-798c8ba2c52642738a0fa2d555ccfc32
Source noteuspto-grants-2015_03