HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-2,2-dimethylpropanoyl chloride → 5-(4-ethylphenyl)-1-(3-fluoro-2,2-dimethylpropanoyl)-N-phenylpiperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-2,2-dimethylpropanoyl chloride | HCID 13935245 | — |
| Reactant | 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide | HCID 66701553 | — |
| Product | 5-(4-ethylphenyl)-1-(3-fluoro-2,2-dimethylpropanoyl)-N-phenylpiperidine-3-carboxamide | HCID 66761216 | — |
Reaction Steps
62 mg (0.20 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 42 mg (0.3 mmol, 1.5 eq.) of 3-fluoro-2,2-dimethylpropanoyl chloride were reacted according to General Method 2. Yield: 68 mg (83% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5f060b9702654df49ccf49bc6fa0ec04 |
| Source note | uspto-grants-2015_03 |