HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxane-4-carbonyl chloride → 5-(4-Ethylphenyl)-N-phenyl-1-(tetrahydro-2H-pyran-4-ylcarbonyl)piperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxane-4-carbonyl chloride | HCID 2795505 | — |
| Reactant | 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide | HCID 66701553 | — |
| Product | 5-(4-Ethylphenyl)-N-phenyl-1-(tetrahydro-2H-pyran-4-ylcarbonyl)piperidine-3-carboxamide | HCID 66761088 | — |
Reaction Steps
62 mg (0.18 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 41 mg (0.27 mmol, 1.5 eq.) of tetrahydro-2H-pyran-4-carbonyl chloride were reacted according to General Method 2. Yield: 67 mg (88% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4887af8f012546a092cf5262456b4e6c |
| Source note | uspto-grants-2015_03 |