HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid → tert-Butyl (1-{[3-(4-ethylphenyl)-5-(phenylcarbamoyl)piperidin-1-yl]carbonyl}cyclopropyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| Reactant | 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide | HCID 66701553 | — |
| Product | tert-Butyl (1-{[3-(4-ethylphenyl)-5-(phenylcarbamoyl)piperidin-1-yl]carbonyl}cyclopropyl)carbamate | HCID 70854693 | — |
Reaction Steps
169 mg (0.50 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 111 mg (0.55 mmol, 1.1 eq.) of 1-[(tert-butoxycarbonyl)amino]cyclopropanecarboxylic acid were reacted according to General Method 1. Yield: 119 mg (48% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-95888960c2a14dfb9a488cfe02ae5de4 |
| Source note | uspto-grants-2015_03 |