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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876272Generated: October 30, 2026

(+-)-Tetrahydro-2-furoic acid → 5-(4-Ethylphenyl)-N-phenyl-1-(tetrahydrofuran-2-ylcarbonyl)piperidine-3-carboxamide

https://huagongshe.com/reaction/876272

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(+-)-Tetrahydro-2-furoic acidHCID 86079—
Reactant5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamideHCID 66701553—
Product5-(4-Ethylphenyl)-N-phenyl-1-(tetrahydrofuran-2-ylcarbonyl)piperidine-3-carboxamideHCID 66761285—

Reaction Steps

68 mg (0.20 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 26 mg (0.22 mmol, 1.1 eq.) of tetrahydrofuran-2-carboxylic acid were reacted according to General Method 1. Yield: 67 mg (81% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987248B2
Source datasetuspto-grants-2015_03
ORD IDord-68a8be30bc7545cfa5a2a95aded65ec2
Source noteuspto-grants-2015_03