2-Methoxyethyl chloroformate → HCID 66761436, compound

HRID 876282Notes

Reaction equation

HRID 876282 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:16])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].Cl[C:25]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26]>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:10][CH:11]([C:15](=[O:16])[NH:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:12][N:13]([C:25]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[CH2:14]2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 694002-Methoxyethyl chloroformateHCID 667015535-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide

Product 1

HCID 66761436HCID 66761436, compound

Procedure

68 mg (0.20 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 38 mg (0.22 mmol, 1.1 eq.) of 2-methoxyethyl chloroformate were reacted according to General Method 5. Yield: 73 mg (89% of theory)

Sources & evidence

ORD record
ord-dde546c72d8f4603932ab15c97f65c88
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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