HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzoic Acid → N-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-3-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzoic Acid | HCID 9968 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate | HCID 66701078 | — |
| Product | N-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-3-fluorobenzamide | HCID 66701342 | — |
Reaction Steps
83 mg (75% pure, 0.15 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate (Example 12A) and 23 mg (0.17 mmol, 1.1 eq.) of 3-fluorobenzoic acid were reacted according to General Method 1. Yield: 41 mg (65% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-94360309ec6f4e4aa7bf384e491c3f68 |
| Source note | uspto-grants-2015_03 |