HRID876292

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734388

3-(Trifluoromethyl)phenylboronic acid

C7H6BF3O2

结构：CCc1ccc(C2CC(NC(=O)c3ccc(Br)cn3)CN(C(=O)C3CCCC3)C2)cc1

HCID66761509

未命名化合物

PRODUCTS

生成物

结构：CCc1ccc(C2CC(NC(=O)c3ccc(-c4cccc(C(F)(F)F)c4)cn3)CN(C(=O)C3CCCC3)C2)cc1

HCID46931634

未命名化合物

PROCEDURE

实验过程

59 mg (0.12 mmol) of 5-bromo-N-[1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]pyridine-2-carboxamide (Example 82) and 27 mg (0.14 mmol, 1.2 eq.) of [3-(trifluoromethyl)phenyl]boronic acid were reacted according to General Method 7. Yield: 46 mg (71% of theory)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8a170ac85cd45d183e955c35984cdd0
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987248B2
来源说明: uspto-grants-2015_03

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]([NH:10][CH:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=3)[CH2:14][N:13]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[O:26])[CH2:12]2)=[O:9])=[N:6][CH:7]=1.[F:32][C:33]([F:44])([F:43])[C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][CH:39]=1>>[CH:27]1([C:25]([N:13]2[CH2:14][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=3)[CH2:16][CH:11]([NH:10][C:8]([C:5]3[CH:4]=[CH:3][C:2]([C:38]4[CH:37]=[CH:36][CH:35]=[C:34]([C:33]([F:44])([F:43])[F:32])[CH:39]=4)=[CH:7][N:6]=3)=[O:9])[CH2:12]2)=[O:26])[CH2:31][CH2:30][CH2:29][CH2:28]1