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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876293Generated: October 29, 2026

5-(3-Fluorophenyl)picolinic acid → N-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-5-(3-fluorophenyl)pyridine-2-carboxamide

https://huagongshe.com/reaction/876293

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(3-Fluorophenyl)picolinic acidHCID 46313125—
Reactant5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetateHCID 66701078—
ProductN-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-5-(3-fluorophenyl)pyridine-2-carboxamideHCID 66701382—

Reaction Steps

62 mg (0.11 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate (Example 12A) and 27 mg (0.12 mmol, 1.1 eq.) of 5-(3-fluorophenyl)pyridine-2-carboxylic acid were reacted according to General Method 1. Yield: 31 mg (56% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987248B2
Source datasetuspto-grants-2015_03
ORD IDord-c391a429ba5c43c4907d2b5ca8dbdd25
Source noteuspto-grants-2015_03