HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl-1,3-thiazole-5-carboxylic acid → N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl-1,3-thiazole-5-carboxylic acid | HCID 736488 | — |
| Reactant | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate | HCID 66701344 | — |
| Product | N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide | HCID 66761399 | — |
Reaction Steps
65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 21 mg (0.13 mmol, 0.9 eq.) of 2,4-dimethyl-1,3-thiazole-5-carboxylic acid were reacted according to General Method 1. Yield: 43 mg (73% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-f0b58fa1aebb4dda8f9a3438cb639575 |
| Source note | uspto-grants-2015_03 |