HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → N-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-3-phenylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate | HCID 66701078 | — |
| Product | N-[5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]-3-phenylurea | HCID 66761956 | — |
Reaction Steps
125 mg (50% pure, 0.15 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate (Example 12A) and 21 mg (0.18 mmol, 1.2 eq.) of phenyl isocyanate were reacted according to General Method 4. Yield: 58 mg (92% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2129f706b67e42afb3f8e2d4ec0d25f6 |
| Source note | uspto-grants-2015_03 |