HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamic chloride, N-methyl-N-phenyl- → 3-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-1-methyl-1-phenylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamic chloride, N-methyl-N-phenyl- | HCID 77969 | — |
| Reactant | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate | HCID 66701344 | — |
| Product | 3-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-1-methyl-1-phenylurea | HCID 46931633 | — |
Reaction Steps
60 mg (0.14 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 22 mg (0.14 mmol, 1.0 eq.) of methyl(phenyl)carbamoyl chloride were reacted according to General Method 3. Yield: 37 mg (69% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-de69b6571ad644d186feca8e15691b68 |
| Source note | uspto-grants-2015_03 |