tert-Butyl isocyanate → HCID 66761545, compound

HRID 876302Notes

Reaction equation

HRID 876302 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][CH:22]=3)[CH2:18][CH:17]([NH2:29])[CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[C:30]([N:34]=[C:35]=[O:36])([CH3:33])([CH3:32])[CH3:31]>>[C:30]([NH:34][C:35]([NH:29][CH:17]1[CH2:18][CH:19]([C:21]2[CH:22]=[CH:23][C:24]([CH2:27][CH3:28])=[CH:25][CH:26]=2)[CH2:20][N:15]([C:13]([CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12]2)=[O:14])[CH2:16]1)=[O:36])([CH3:33])([CH3:32])[CH3:31]

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 667013441-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate

Product 1

HCID 66761545HCID 66761545, compound

Procedure

108 mg (0.22 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 7A) and 26 mg (0.26 mmol, 1.2 eq.) of tert-butyl isocyanate were reacted according to General Method 4. Yield: 69 mg (78% of theory)

Sources & evidence

ORD record
ord-98d79a1ec86e44c4b77b3a26cb0ae459
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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