HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Morpholinecarbonyl chloride → Methyl [5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidin-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Morpholinecarbonyl chloride | HCID 84810 | — |
| Reactant | Methyl [5-(4-ethylphenyl)piperidin-3-yl]carbamate | HCID 68074779 | — |
| Product | Methyl [5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidin-3-yl]carbamate | HCID 68075447 | 32.1% |
Reaction Steps
170 mg (0.58 mmol) of methyl [5-(4-ethylphenyl)piperidin-3-yl]carbamate (Example 21A) and 113 mg (0.76 mmol, 1.3 eq.) of morpholine-4-carbonyl chloride were reacted according to General Method 3. Diastereomer separation of the cis/trans isomer mixture according to Method 7C gave 70 mg of the compound from Example 102.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-8773ac48f44f4e5d880e8e2f45a7dd83 |
| Source note | uspto-grants-2015_03 |