Phenyl chloroformate → HCID 68074844, compound

HRID 876308Notes

Reaction equation

HRID 876308 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([C:10]1[CH:15]=[CH:14][C:13]([CH:16]2[CH2:21][N:20]([C:22]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[O:23])[CH2:19][CH:18]([NH2:29])[CH2:17]2)=[CH:12][CH:11]=1)[CH3:9].Cl[C:31]([O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:32]>>[CH2:8]([C:10]1[CH:11]=[CH:12][C:13]([CH:16]2[CH2:21][N:20]([C:22]([N:24]3[CH2:25][CH2:26][CH2:27][CH2:28]3)=[O:23])[CH2:19][CH:18]([NH:29][C:31](=[O:32])[O:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:17]2)=[CH:14][CH:15]=1)[CH3:9]

Participants

3

Reactant 2

HCID 15891Phenyl chloroformateHCID 667010785-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate

Product 1

HCID 68074844HCID 68074844, compound

Procedure

83 mg (0.15 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-amine trifluoroacetate (Example 12A) and 26 mg (0.17 mmol, 1.1 eq.) of phenyl chloroformate were reacted according to General Method 5. Yield: 25 mg (39% of theory)

Sources & evidence

ORD record
ord-d8b8a815515f4c8da84dda70da4c69bf
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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