Water → HCID 66761321, compound

Participants

Reaction Steps

At 0° C., 180 mg (0.54 mmol) of N-{5-[3-(1-methylethyl)phenyl]piperidin-3-yl}benzamide were initially charged in 4 ml of dichloromethane, and 162 mg (1.08 mmol) of morpholine-4-carbonyl chloride and 114 μl (0.81 mmol) of triethylamine were added. The mixture was slowly warmed to RT overnight. Water was added, and the reaction mixture was extracted. The organic phase was dried over magnesium sulphate and concentrated under reduced pressure. The residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 121 mg (51% of theory)

Provenance & Evidence