Triethylamine → 3-[(Phenylcarbonyl)amino]-N-(tetrahydrofuran-2-ylmethyl)-5-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide

Participants

Reaction Steps

80 mg (0.23 mmol) of ethyl-N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide were initially charged in 2 ml of THF, and 29 mg (0.23 mmol) of 2-(isocyanatomethyl)tetrahydrofuran and 35 μl (0.25 mmol) of triethylamine were added. The mixture was stirred at RT overnight. The reaction mixture was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 88 mg (81% of theory)

Provenance & Evidence