Lithium Hydroxide → HCID 46931521, compound

Participants

Reaction Steps

27 mg (0.05 mmol) of methyl 1-({3-[(phenylcarbonyl)amino]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)piperidine-4-carboxylate were initially charged in 0.8 ml each of THF and water, and 4 mg (0.15 mmol) of lithium hydroxide were added. The mixture was stirred at RT overnight. The reaction solution was concentrated under reduced pressure and acidified, and the precipitate was filtered off and dried. Yield: 16 mg (62% of theory)

Provenance & Evidence