3-Cyanobenzoic acid → HCID 66761605, compound

HRID 876342Notes

Reaction equation

HRID 876342 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH2:6][N:5]([C:19]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:20])[CH2:4]1.[C:27]([C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](O)=[O:33])#[N:28]>>[C:27]([C:29]1[CH:30]=[C:31]([C:32]([NH:2][CH:3]2[CH2:8][CH:7]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][CH:10]=3)[CH2:6][N:5]([C:19]([N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)=[O:20])[CH2:4]2)=[O:33])[CH:35]=[CH:36][CH:37]=1)#[N:28]

Participants

3

Reactant 2

HCID 158753-Cyanobenzoic acidHCID 66761974HCID 66761974, compound

Product 1

HCID 66761605HCID 66761605, compound

Procedure

200 mg (0.508 mmol) of the amine from Example 57A [racemic cis isomer] and 112 mg (0.762 mmol) of 3-cyanobenzoic acid were reacted according to General Method 8. Yield: 206 mg (80% of theory)

Sources & evidence

ORD record
ord-dccc15d426d540dba0bf89e3be8454e7
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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