5-Cyanopyridine-2-carboxylic acid → HCID 71112644, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 1, the condensation of (S)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate F8.1) and 5-cyanopicolinic acid yielded the title compound (35 mg, 74% yield) as a light yellow foam. MS (ISP): m/z=408.4 [M+H]+.

Provenance & Evidence