Sodium periodate → HCID 86654356, compound

HRID 876389Notes

Reaction equation

HRID 876389 reaction equation
I([O-])(=O)(=O)=O.[Na+].[Si:7]([O:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:24]=1[N:23]=[C:22]([C:25]1[N:29]3[CH:30]=[CH:31][C:32]([CH:34]([OH:37])CO)=[CH:33][C:28]3=[N:27][N:26]=1)[CH:21]=[CH:20]2)([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]>C(Cl)Cl>[Si:7]([O:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:24]=1[N:23]=[C:22]([C:25]1[N:29]3[CH:30]=[CH:31][C:32]([CH:34]=[O:37])=[CH:33][C:28]3=[N:27][N:26]=1)[CH:21]=[CH:20]2)([C:10]([CH3:11])([CH3:12])[CH3:13])([CH3:8])[CH3:9]

Participants

4

Reactant 2

HCID 23667635Sodium periodateHCID 67231553HCID 67231553, compound

Product 1

HCID 86654356HCID 86654356, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Sodium periodate (6.060 mL, 3.939 mmol) was added to silica gel (6 g) in DCM (10 mL), affording a slurry. 1-(3-(8-(tert-butyldimethylsilyloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl)ethane-1,2-diol (1.433 g, 3.282 mmol) in DCM (10 mL) was added to the slurry and the reaction was stirred for 1 hour. The silica gel was removed by filtration and washed with DCM. The filtrate was concentrated in vacuo to provide the crude product.

Workup

  1. customaffording a slurry
  2. customThe silica gel was removed by filtration
  3. washwashed with DCM
  4. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-24f51882f4184569935db4f356349b78
Source dataset
uspto-grants-2015_03
Patent number
US08987251B2

Reaction notes

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