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HRID876408

反应详情

EQUATION

反应方程式

HRID 876408 的结构方程式

REACTANTS

反应物

2
结构：NNc1ccccn1
HCID78645

2-Hydrazinopyridine

C5H7N3

结构：CC(C)[Si](Oc1cc(F)cc2ccc(C=O)nc12)(C(C)C)C(C)C
HCID86638610

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[Si](Oc1cc(F)cc2ccc(C=NNc3ccccn3)nc12)(C(C)C)C(C)C
HCID67229707

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

6-Fluoro-8-(triisopropylsilyloxy)quinoline-2-carbaldehyde (15.0 g, 43.2 mmol) and 2-hydrazinylpyridine (4.71 g, 43.2 mmol) were combined in 100 mL of anhydrous EtOH, and stirred at ambient temperature over night. Following over night stirring, the desired product was collected by filtration (washing with cold EtOH), affording 6-fluoro-2-((2-(pyridin-2-yl)hydrazono)methyl)-8-(triisopropylsilyloxy)quinoline (14.0 g, 31.9 mmol, 74% yield) as a yellow-white powder.

WORKUP

后处理

  1. waitFollowing over night
  2. stirringstirring
  3. filtrationthe desired product was collected by filtration (washing with cold EtOH)