Hydrochloric Acid → HCID 58303650, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)-5-fluoroazepane-1-carboxylate (0.157 g, 0.329 mmol) in CHCl3 (3.2 mL) was added HCl (3.29 mL, 13.2 mmol, 4.0 M in dioxane). The mixture was stirred at ambient temperature for 5 hours and was then filtered directly. The solid was washed with CH2Cl2 (5 mL) and Et2O (5 mL) and carefully dried in vacuo to afford the desired product as an off-white solid. The salt was purified directly by column chromatography (10% MeOH/CH2Cl2 with 1% NH3) to provide the free amine product as an off-white solid. MS ESI (+) m/z 378.1 (M+1) detected.

Provenance & Evidence