2-Hydrazinopyridine → HCID 67233679, compound

HRID 876434Notes

Reaction equation

HRID 876434 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=O)=[N:9]2)=[CH:4][CH:3]=1.[NH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[NH2:23]>CCO>[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:23][NH:22][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 86654355HCID 86654355, compound

Product 1

HCID 67233679HCID 67233679, compoundYield 80.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the product from Step C (2.95 g, 8.05 mmol) was added EtOH (30 mL, anhydrous). To this solution was added 2-hydrazinylpyridine (0.967 g, 8.86 mmol). The mixture was stirred at ambient temperature for 24 hours. The resulting precipitate was isolated by vacuum filtration, washed with cold EtOH and then dried in vacuo to afford 2.98 g (73%) of the product.

Workup

  1. customThe resulting precipitate was isolated by vacuum filtration
  2. washwashed with cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-012507588f744c1c9333f0970b5111a4
Source dataset
uspto-grants-2015_03
Patent number
US08987251B2

Reaction notes

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