Iodo benzene diacetate → HCID 67234839, compound

HRID 876435Notes

Reaction equation

HRID 876435 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:21][NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[N:9]2)=[CH:4][CH:3]=1.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1>C(Cl)Cl>[N:22]1[N:21]=[C:20]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:17])[CH3:18])([CH3:15])[CH3:14])[C:2]([Br:1])=[CH:3][CH:4]=3)[N:9]=2)[N:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=12

Participants

4

Reactant 2

HCID 12217721Iodo benzene diacetateHCID 67233679HCID 67233679, compound

Product 1

HCID 67234839HCID 67234839, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product from Step D (2.95 g, 6.45 mmol) was added CH2Cl2 (60 mL). Iodobenzene diacetate (2.28 g, 7.09 mmol) was added and the mixture stirred at ambient temperature overnight. The mixture was concentrated and the product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2) to afford 2.87 g (88%) of the product.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-4189c92910404d98a4a8eff30e27d700
Source dataset
uspto-grants-2015_03
Patent number
US08987251B2

Reaction notes

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