HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate → (S)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoro-8-(piperidin-3-ylmethoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate | HCID 1514448 | — |
| Reactant | 2-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-ol | HCID 136337805 | — |
| Product | (S)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoro-8-(piperidin-3-ylmethoxy)quinoline | HCID 58303761 | — |
Reaction Steps
Prepared as described in Example 16 using (S)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate in place of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate, and 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-ol in place of 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-quinolin-8-ol. MS ESI (+) m/z 378.2 (M+1) detected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987251B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-253cc204d5464c70998ca5b8d2ea79a4 |
| Source note | uspto-grants-2015_03 |