反应详情

温度

160 °C

N-(2-Fluorophenyl)cinnamamide (97.2 g, 403 mmol) was combined with AlCl3 (161 g, 1209 mmol) and the solids were thoroughly mixed. The dry mixture was heated to 160° C. for 100 minutes. The reaction was cooled and quenched by addition of ice. A beige solid formed after complete dispersion of the dark solids and this was stirred overnight. The beige solid was filtered and air-dried overnight to provide the desired product as a free-flowing solid (69.8 g).

1. additionthe solids were thoroughly mixed
2. temperatureThe reaction was cooled
3. customquenched by addition of ice
4. customA beige solid formed after complete dispersion of the dark solids
5. filtrationThe beige solid was filtered
6. customair-dried overnight