MeOH tetrahydrofuran → HCID 58477273, compound

Participants

Reaction Steps

A solution of OXONE (3.7 g, 6 mmol) in H2O (15 ml) was added drop wise to a solution of (E)-1-(2-hydroxy-3-nitrophenyl)-3-(2-(methylthio)phenyl)prop-2-en-1-one 15 (315 mg, 1.0 mmol) in THF/MeOH (35 mL, 1:1) at room temperature. The reaction mixture was stirred for 12 h. The volatiles were removed under reduced pressure and the resulting precipitate was collected by filtration, rinsed with H2O and dried under vacuum. The crude residue was purified by flash chromatography eluting with CH2Cl2/MeOH (0-1%) to give 16 as a yellow solid (200 mg, yield 58%).

Provenance & Evidence