HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876531Generated: October 30, 2026
Hydrochloric Acid → 1-(2-Hydroxy-3-nitrophenyl)-3-(2-(trifluoromethyl)pyridin-3-yl)propane-1,3-dione
https://huagongshe.com/reaction/876531
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-(2-Hydroxy-3-nitrophenyl)-ethanone | HCID 270026 | — |
| Reactant | 2-(Trifluoromethyl)nicotinoyl chloride | HCID 45081951 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-(2-Hydroxy-3-nitrophenyl)-3-(2-(trifluoromethyl)pyridin-3-yl)propane-1,3-dione | HCID 58477272 | 38.1% |
Reaction Steps
DBU (334 mg, 2.2 mmol) was added to a solution of 1-(2-Hydroxy-3-nitrophenyl)ethanone 1 (181 mg, 1 mmol) and 2-(trifluoromethyl)pyridine-3-carbonyl chloride 25 (1.1 mmol) in pyridine (3 ml). The mixture was stirred at 70° C. for 12 h, poured into 2N HCl (20 ml) and extracted with EtOAc. The organic layers were dried over Na2SO4, concentrated and purified by preparative TLC (CH2Cl2/EtOAc, 10:1) to give 26 as a yellow solid (135 mg, 38% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987258B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-8d12561489ed4d96aee1642e0e99487e |
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| Source note | uspto-grants-2015_03 |
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