HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876533Generated: October 29, 2026
Methanol → 8-amino-2-(2-(trifluoromethyl)pyridin-3-yl)-4H-chromen-4-one
https://huagongshe.com/reaction/876533
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 8-nitro-2-(2-(trifluoromethyl)pyridin-3-yl)-4H-chromen-4-one | HCID 58477305 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 8-amino-2-(2-(trifluoromethyl)pyridin-3-yl)-4H-chromen-4-one | HCID 58477333 | 77.3% |
Reaction Steps
A mixture of 8-nitro-2-(2-(trifluoromethyl)pyridin-3-yl)-4H-chromen-4-one 27 (118 mg, 0.38 mmol), Fe (96 mg, 1.7 mmol), sat. aq NH4Cl (7 mL) and MeOH (14 mL) was stirred at 90° C. for 2 h. After cooling to room temperature the reaction mixture was poured into EtOAc and the layers separated. The organic layer was dried (MgSO4) and concentrate to give 28 as a yellow solid (90 mg, 77% yield over two steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987258B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-871c0ed7a02e45baa1f83c300d4ff084 |
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| Source note | uspto-grants-2015_03 |
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