反应详情

3-acetyl-5-bromo-2-hydroxybenzoic acid 31 (50 g, 0.19 mol) was dissolved in 250 mL ethanol. After addition of 5.0 g 10% Pd/C the reaction mixture was hydrogenated under 15 atm H2-pressure at room temperature for 6 h. The catalyst was filtered and the solvent was evaporated. The residue was poured into H2O and extracted with CH2Cl2. The combined organic phase was dried and the solvent was removed to give 32 (28 g, 85% yield)

1. filtrationThe catalyst was filtered
2. customthe solvent was evaporated
3. additionThe residue was poured into H2O
4. extractionextracted with CH2Cl2
5. customThe combined organic phase was dried
6. customthe solvent was removed