HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876542Generated: October 30, 2026
Water → Methyl 2-hydroxy-3-(3-oxo-3-(2-(trifluoromethyl)pyridin-3-yl)propanoyl)benzoate
https://huagongshe.com/reaction/876542
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Methyl 3-acetyl-2-hydroxybenzoate | HCID 13037297 | — |
| Reactant | 2-(Trifluoromethyl)nicotinoyl chloride | HCID 45081951 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Methyl 2-hydroxy-3-(3-oxo-3-(2-(trifluoromethyl)pyridin-3-yl)propanoyl)benzoate | HCID 58477324 | 111.9% |
Reaction Steps
2-(trifluoromethyl)pyridine-3-carbonyl chloride 25 (300 mg, 1.46 mmol) was added to a mixture of methyl 3-acetyl-2-hydroxybenzoate 38 (183 mg, 1.46 mmol) and DBU (446 mg, 2.92 mmol) in pyridine at 0° C. The reaction mixture was heated at 80° C. for 12 h. The resulting mixture was poured into H2O and extracted with ethyl acetate. The organic layer was dried (MgSO4) and concentrated to give 39 (600 mg) which was used with no further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987258B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-d08636f33b3248f983e03ed7ac4fe129 |
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| Source note | uspto-grants-2015_03 |
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