Water → HCID 58477232, compound

Participants

Reaction Steps

LiOH.H2O (28 mg, 0.64 mmol) was added to a solution of methyl 4-oxo-2-(2-(trifluoromethyl)pyridin-3-yl)-4H-chromene-8-carboxylate 40 (120 mg, 0.32 mmol) in H2O/THF/MeOH (5 mL, 1:2:2). The reaction mixture was stirred at ambient temperature for 12 h, poured into H2O and the pH adjusted to 3. The mixture was extracted with ethyl acetate, dried (MgSO4) and concentrated to give 41 (120 mg) which was with no further purification.

Provenance & Evidence