HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876552Generated: October 29, 2026
Hydrochloric Acid → 6-(Pyrrolidin-1-ylmethyl)picolinic acid
https://huagongshe.com/reaction/876552
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 15123266 | HCID 15123266 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 6-(Pyrrolidin-1-ylmethyl)picolinic acid | HCID 46318234 | 80.1% |
Reaction Steps
A mixture of methyl 6-(pyrrolidin-1-ylmethyl)picolinate 73 (36 g) and NaOH (40 g, 1.0 mol) in ethanol/H2O (320 mL) was stirred at 75° C. for 16 h. The pH was adjusted to 7 with 3N HCl and extracted with EtOAc. The aqueous layer was concentrated to dryness and extracted with dichloromethane/methanol (v:v=3:1), The organic layer was dried to give 74 (27 g, 55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987258B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-90727b22a5634900b5310f687a8e0f31 |
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| Source note | uspto-grants-2015_03 |
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