反应详情

温度

80 °C

To a suspension of compound 14-4 (80 mg) in THF—H2O (2 mL-0.67 mL), were added 2-thiopheneboronic acid (43 mgl), Cs2CO3 (0.44 g), and Pd(Ph3P)4 (19.4 mg). The mixture was stirred at 80° C. for 15 hours. The reaction mixture was filtered with Celite® pad and rinsed with the mixed solvent (EtOAc-MeOH=1-1). The filtrate was concentrated in vacuo and the resulting residue was washed with H2O and Et2O. The precipitate was collected by filtration to obtain compound 22-1 (35 mg) as a pale brown amorphous solid.

1. filtrationThe reaction mixture was filtered with Celite® pad
2. washrinsed with the mixed solvent (EtOAc-MeOH=1-1)
3. concentrationThe filtrate was concentrated in vacuo
4. washthe resulting residue was washed with H2O and Et2O
5. filtrationThe precipitate was collected by filtration