HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876573Generated: October 26, 2026
Potassium cyanate → (2R)-2-[(2R)-4-[4-(carbamoylamino)phenyl]-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamide
https://huagongshe.com/reaction/876573
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium cyanate | HCID 11378442 | — |
| Reactant | (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamide | HCID 67032877 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetic acid--water (1/1) | HCID 21899381 | — |
| Product | (2R)-2-[(2R)-4-[4-(carbamoylamino)phenyl]-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamide | HCID 67223031 | 89.5% |
Reaction Steps
To a solution of compound 26-5 (70 mg) in AcOH—H2O (6 mL-2 mL), was added a solution of potassium cyanate (KOCN; 31 mg) in water (2 mL). The reaction mixture was stirred at 40-50° C. for 3 hours and at room temperature overnight to precipitate. The resulting precipitate was collected by filtration, rinsed with waster and dried in vacuo to obtain compound 27-1 (70 mg) as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987242B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-7848b6ddedf045a5b7bd6554cde0b8dc |
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| Source note | uspto-grants-2015_03 |
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