HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 67033352, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(1,1-Dimethylethyl) (2R,3R)-2,3-bis(acetyloxy)butanedioate | HCID 14143476 | — |
| Reactant | HCID 67223625 | HCID 67223625 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67033352 | HCID 67033352 | 105.3% |
Reaction Steps
To a solution of (R,R)-2,3-bis(acetyloxy)-butanedioic acid mono tert-butyl ester (9 g: Tetrahedron, 45, 3071-3080, 1989) in CH2Cl2 (90 mL), were added compound 11-1 (6.6 g) and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride at 0° C. The reaction mixture was stirred for 5 hours at room temperature. Then water was added into the mixture and it was extracted with CH2Cl2. The organic layer was washed with brine, dried with anhyd. Na2SO4. The solvent was removed under reduced pressure to obtain compound 52-1 (15.8 g) as a brown amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-865d8f289fb0475b984eb1dcd1185d69 |
| Source note | uspto-grants-2015_03 |