HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → tert-butyl (2R)-2-[(2R)-4-(4-chlorophenyl)-3-oxomorpholin-2-yl]-2-hydroxyacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-butyl (2R,3R)-4-[4-chloro-N-(2-chloroethyl)anilino]-2,3-dihydroxy-4-oxobutanoate | HCID 67223250 | — |
| Solvent | DMSO t-BuOH | HCID 86634320 | — |
| Product | tert-butyl (2R)-2-[(2R)-4-(4-chlorophenyl)-3-oxomorpholin-2-yl]-2-hydroxyacetate | HCID 67222627 | 24.9% |
Reaction Steps
According to the Step 7-5 in synthetic method for EXAMPLE 7, compound 60-4 (1.78 g) and DMF were used instead of 7-4 and t-BuOH-DMSO to obtain compound 60-5 (400 mg) as a pale yellow amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-1f622ecd6ab84a8e9fa7a4930cc1304f |
| Source note | uspto-grants-2015_03 |