反应详情

To a solution of compound 66-2 (19 mg) in EtOH (3 mL), were added cat. Raney-Ni and AcOH (0.1 mL). The mixture was stirred under hydrogen atmosphere for 3 hours at room temperature. The mixture was filtered with Celite® pad to remove catalyst. The filtrate was concentrated with toluene in vacuo. The residue was dried by vacuum pump to obtain EXAMPLE 66 (15 mg) as a colorless amorphous solid.

1. filtrationThe mixture was filtered with Celite® pad
2. customto remove catalyst
3. concentrationThe filtrate was concentrated with toluene in vacuo
4. customThe residue was dried by vacuum pump