1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 136209283, compound

Participants

Reaction Steps

To a solution of compound 70-4 (40 mg) in CH3CN (1 mL) at 0° C. was added 4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl amide (21 mg) followed by EDCI (25 mg). The reaction mixture was warmed to rt and stirred for 72 h. The mixture was concentrated under reduced pressure and placed under high vacuum. The crude material was purified by reverse phase HPLC using a C18 column and a gradient of (89.95:9.95:0.1 H2O:MeCN:HCO2H to 9.95:89.95:0.1 H2O:MeCN:HCO2H) to afford compound 70-5 (30 mg) as a white solid. LC-MS: M+H=522.

Provenance & Evidence