Ammonia methanol → HCID 178479945, compound

HRID 876592Notes

Reaction equation

C([O:4][C@H:5]([C@H:21]1[O:26][CH2:25][CH2:24][N:23]([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[CH2:32][N:31]([CH3:36])[C:30]3=[O:37])[C:22]1=[O:38])[C:6](=[O:20])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[NH:18][C:17](=[O:19])[O:16][N:15]=2)=[CH:10][CH:9]=1)(=O)C.[NH3:39].CO>CO>[OH:4][C@H:5]([C@H:21]1[O:26][CH2:25][CH2:24][N:23]([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[CH2:32][N:31]([CH3:36])[C:30]3=[O:37])[C:22]1=[O:38])[C:6]([NH:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[N:18]=[C:17]([O-:19])[O:16][N:15]=2)=[CH:12][CH:13]=1)=[O:20].[NH4+:39]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of the compound 70-5 (30 mg) in MeOH (2 mL) at 0° C. was added 7M NH3/MeOH (0.3 mL) dropwise. The mixture was stirred for 1 h at 0° C. and an additional hour at rt. The mixture was concentrated under reduced pressure and placed under high vacuum to afford compound 70-6 (27 mg) as a clear glass. LC-MS: M+H=480 (free base).

Workup

concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-03870a2da8b3408a94c405d85a6e6bf4
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987242B2

Reaction notes

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