HRID876593

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2756041

4-(N-Boc-aminomethyl)aniline

C12H18N2O2

结构：CC(=O)O[C@@H](C(=O)O)[C@H]1OCCN(c2ccc3c(c2)C(=O)N(C)C3)C1=O

HCID58181678

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O[C@@H](C(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1)[C@H]1OCCN(c2ccc3c(c2)C(=O)N(C)C3)C1=O

HCID58182005

未命名化合物

收率 74.2%

PROCEDURE

实验过程

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 70-4 (50 mg) was treated with tert-butyl 4-aminobenzylcarbamate (37 mg) to afford compound 71-1 (58 mg) as white solid after preparative LC purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2e46875f7c454cba8a6318541e69a199
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([OH:8])=O)(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:42]=[CH:41][C:31]([CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:30][CH:29]=1>>[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([NH:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:32][NH:33][C:34]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:40])=[CH:41][CH:42]=1)=[O:8])(=[O:3])[CH3:2]