tert-butyl N-[(4-aminophenyl)methyl]carbamate → HCID 58182005, compound

HRID 876593Notes

Reaction equation

HRID 876593 reaction equation
[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([OH:8])=O)(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:42]=[CH:41][C:31]([CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:30][CH:29]=1>>[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([NH:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:32][NH:33][C:34]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:40])=[CH:41][CH:42]=1)=[O:8])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2756041tert-butyl N-[(4-aminophenyl)methyl]carbamateHCID 58181678HCID 58181678, compound

Product 1

HCID 58182005HCID 58182005, compoundYield 74.2%

Procedure

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 70-4 (50 mg) was treated with tert-butyl 4-aminobenzylcarbamate (37 mg) to afford compound 71-1 (58 mg) as white solid after preparative LC purification.

Sources & evidence

ORD record
ord-2e46875f7c454cba8a6318541e69a199
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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