3-Iodobenzoic acid → HCID 58182065, compound

HRID 876598Notes

Reaction equation

HRID 876598 reaction equation
[F:1][C:2]1([F:17])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12](I)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.[I:18]C1C=C(C=CC=1)C(O)=O.FC1(F)CCNCC1>>[F:1][C:2]1([F:17])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([I:18])=[CH:12][CH:11]=2)=[O:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 120603-Iodobenzoic acidHCID 27583524,4-DifluoropiperidineHCID 58181859HCID 58181859, compound

Product 1

HCID 58182065HCID 58182065, compound

Procedure

According to Step 77-1 in the synthetic method for compound 77-1, 4-iodobenzoic acid 1 and 4,4-difluoropiperidine 2 were used to obtain compound 83-1.

Sources & evidence

ORD record
ord-9a35e3bf31994a4b9346c23c55f32b42
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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