1,2,3,4-Tetrahydroisoquinoline → HCID 59548650, compound

HRID 876599Notes

Reaction equation

HRID 876599 reaction equation
F[C:2]1(F)[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([I:16])[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.I[C:19]1[CH:20]=C(C=C[CH:27]=1)C(O)=O.C1C2C(=CC=CC=2)CCN1>>[I:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:4][C:3]3[C:7](=[CH:2][CH:27]=[CH:19][CH:20]=3)[CH2:6]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 120603-Iodobenzoic acidHCID 58181859HCID 58181859, compound

Product 1

HCID 59548650HCID 59548650, compound

Procedure

According to Step 77-1 in the synthetic method for compound 77-1, 3-iodobenzoic acid 1 and morpholine 2 were used to obtain compound 85-1.

Sources & evidence

ORD record
ord-675212b917914bed9c8c9397709b85c6
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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